Dose growth phase of the review: subjects have to have relapsed/refractory RMS or even a solid malignant tumor (Ewing sarcoma, hepatoblastoma, neuroblastoma and Wilms tumor) wherein procedure with vincristine/irinotecan is considered spine chemotherapy at relapse and also a scientific rationale to combine vincristine/irinotecan with regorafenib exists. Estrogens minimize osteoclast se... https://acbi132108.ltfblog.com/20165939/details-fiction-and-eganelisib