You will find there's release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to reduce afferent suffering transmission and make analgesia. Therefore, medications like clonidine that focus on alpha-2 receptors can influence the transmission of soreness. Can be presented as monotherapy https://chesterd173yqf9.azuria-wiki.com/user