Lousy/Extensive Metabolizers, CYP2D6 The development of your active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About 7% of the population has reduced activity on the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These people are “lousy metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, between other medicines. e., https://bethx196zfk2.bloggactif.com/profile